International Journal For Multidisciplinary Research

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Studies on Formulation and Evaluation of Inlay Tablet for Delivery of an Antidiabetic Drug

Author(s) Mahesh Dilip Mane, Nilesh Shashikant Patole, Vetal Nana Kodlkar
Country India
Abstract The main objective of the present research work was to develop a inlay tablet containing immediate release core tablet of Glyburide and sustained release cup portion of Metformin Hydrochloride, which is used as an Anti-hyperglycemic agent. Metformin Hydrochloride has biological half-life nearly about 6 hours, so an attempt was made in the direction of preparation and optimization of a combination of sustained release and immediate release in a single tablet. Hydroxy propyl methyl cellulose K100 and Hydroxy propyl methyl cellulose K4M were used as retarding materials and in immediate release sodium starch glycolate, cross carmellose sodium and crospovidone was used as a super disintegrants to give the faster release of Glyburide. Final formulation showed release of drug up to 95.75% in 8 hours. The formulation IT3 was prepared based on optimization and stability study showed no significant changes when stored at 40oC/75%RH for three months according to ICH guidelines. FTIR and DSC studies revealed that there was no interaction between the drugs and polymers. In this study optimized formulation IT3 released the drug till 8 hours.
Keywords Hyperglycemia, inlay tablet, Glyburide, metformin hydrochloride, immediate release, sustained release, wet granulation.
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2025
Published On 2025-01-26
Cite This Studies on Formulation and Evaluation of Inlay Tablet for Delivery of an Antidiabetic Drug - Mahesh Dilip Mane, Nilesh Shashikant Patole, Vetal Nana Kodlkar - IJFMR Volume 7, Issue 1, January-February 2025. DOI 10.36948/ijfmr.2025.v07i01.35827
DOI https://doi.org/10.36948/ijfmr.2025.v07i01.35827
Short DOI https://doi.org/g829qn
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