International Journal For Multidisciplinary Research

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Naeglera fowleri (The Brain-eating Amoeba): Pathogenesis, Diagnosis, Treatment by using Rifampin and Side effects in humans

Author(s) Parnab Singha, Rajshri Patel, Tanima Das
Country India
Abstract Naegleria fowleri, often referred to as the "brain-eating amoeba," is a free-living amoeba (FLA) capable of invading the cerebrospinal axis (CNS), leading to a rapidly progressing and severe infection known as primary amoebic meningoencephalitis (PAM). Although the incidence of PAM is low, it is associated with an extraordinarily high mortality rate of approximately 98%, with affected individuals typically succumbing to the infection within two weeks of initial exposure. This review aims to provide a comprehensive overview of the latest research on Naegleria fowleri, focusing on its pathogenesis and diagnosis, treatment of that disease by using Rifampin drug and side effects of that drug in human body. Additionally, we explore current therapeutic strategies, with particular emphasis on the potential role of immunomodulatory agents in reducing neurological damage and improving patient outcomes. Through a deeper interpret of the technique by which this unicellular organism causes harm to the cerebrospinal axis, as well as the exploration of novel treatment avenues, there is hope for developing more effective interventions to combat this deadly infection.
Keywords Brain Eating Amoeba, Primary Amoebic Meningoencephalitis, Naegleria fowleri, Rifampin, Immunomodulatory agents
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2025
Published On 2025-02-02
Cite This Naeglera fowleri (The Brain-eating Amoeba): Pathogenesis, Diagnosis, Treatment by using Rifampin and Side effects in humans - Parnab Singha, Rajshri Patel, Tanima Das - IJFMR Volume 7, Issue 1, January-February 2025. DOI 10.36948/ijfmr.2025.v07i01.36342
DOI https://doi.org/10.36948/ijfmr.2025.v07i01.36342
Short DOI https://doi.org/g83xwr
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