International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 7, Issue 2 (March-April 2025) Submit your research before last 3 days of April to publish your research paper in the issue of March-April.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 7 Issue 2
March-April 2025

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Immunoinformatics Approach for the Prediction of Novel Peptide-based Epitope Vaccine Design Against Leishmania Donovani: a Computational Biology Approach

Author(s) Pritismita Mahalik, Muthu Tanya, Shibani Pradhan, Satarupa Routraya, Dharitri Priyadarsini, Rajat Kumar Nayak
Country India
Abstract INTRODUCTION:
A devastating vector-borne parasitic disease that primarily affects tropical and subtropical areas is visceral leishmaniasis (VL). As a neglected tropical disease with rising drug resistance and no approved vaccine, VL falls into this category. Traditional vaccine production methods are frequently exceedingly time-consuming and difficult. Designing multi-epitope vaccines with anticipated immuno-dominant epitopes of various antigenic proteins is now easier thanks to advancements in bioinformatics and their use in immunology. In order to construct an in-silico chimeric vaccine, we have chosen four antigenic proteins from Leishmania donovani and determined their T-cell and B-cell epitopes. The different physicochemical properties of the vaccine have been investigated, and it is anticipated that the tertiary structure of the chimaera construct will facilitate docking investigations and molecular dynamics simulations.
RESULT:
The epitopes are connected with particular linkers to create the vaccine construct. The vaccine's expected tertiary structure has been confirmed to be accurate, and docking experiments have shown that the construct has a strong affinity for the TLR-4 receptor. An examination of population coverage reveals that vaccination can protect the vast majority of people on the planet. The vaccination raises a pro-inflammatory response that results in the multiplication of activated T and B cells, according to in-silico immunological simulation experiments.
CONCLUSION:
The bioinformatics data cited above provide evidence that the design may function as a potential vaccination. To verify vaccine potency, additional wet lab production of the vaccine and in vivo studies in animal models must be carried out.
Keywords Leishmania donovani, B-cell & T-cell epitopes, adjuvant, Disulfide engineering, Molecular Docking
Field Biology > Genetics / Molecular
Published In Volume 5, Issue 3, May-June 2023
Published On 2023-06-10
DOI https://doi.org/10.36948/ijfmr.2023.v05i03.3671
Short DOI https://doi.org/gscdpr
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 7 Isu 2Cover Page Vol 7 Isu 1Cover Page Vol 6 Isu 6

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9687-828-838 editor@ijfmr.com