Docking of Alkaloid as a Source of Potential Anticholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

Sonali Priyadarsini; Debasmita Roy; Priyanka Prusty; Kajal Kiran Sahoo; Dharitri Priyadarsini; Rajat Kumar Nayak

doi:10.36948/ijfmr.2023.v05i03.3676

Docking of Alkaloid as a Source of Potential Anticholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

Author(s)	Sonali Priyadarsini, Debasmita Roy, Priyanka Prusty, Kajal Kiran Sahoo, Dharitri Priyadarsini, Rajat Kumar Nayak
Country	India
Abstract	Alzheimer's dementia affects 6.2 million Americans aged 65 and older, according to estimates. If no medical advances are made to prevent, slow down, or cure AD, this figure might increase to 13.8 million by 2060. The "APP", "APOE4", and "PSEN1" genes, which are responsible for AD, are playing a molecular function in our bodies on chromosomes 21, 19, and 14, depending on whether they are displaying low risk or high risk. This study describes the alternative therapeutic targets, incidence, prevalence, mortality, and morbidity of Alzheimer's disease (AD) and how it affects public health. By using computational methods, it was discovered that the biology underlying those genes. How the Clustal Omega alignment of the sequences of many species gave us 100% identity. The study on the comparative genome viewer based on assembly-assembly alignment published by NCBI came after the Ramachandran plot based on φ and ψ values, where the best model quality was observed by assessing the Q mean or Z score. Once the targets were set, the efficient ligands "ALKALOIDC", "PIPERIDINE", and "SANGUINARINE" in order to continue working on protein structures were studied. One should be familiar with 2D and 3D models of proteins to do this. The demand for new medicines that provide improved symptomatic benefit and disease-slowing capabilities, as well as the identification of several new therapeutic targets, has led to a greater focus on protein-ligand interaction by employing molecular docking. The anticholinesterase activity of alkaloids, together with their structural diversity and physicochemical properties, makes them good candidate agents for the treatment of Alzheimer’s disease. Future research should include more rigorous clinical studies of the most promising alkaloids, the further development of recently discovered candidate alkaloids, and the continual search for new alkaloids for relevant drug targets. It remains promising that an alkaloid drug candidate could significantly affect the progression of AD in addition to providing symptomatic relief.
Keywords	Alzheimer’s Disease, AlkaloidC, Piperidine, Sanguinarine, Anticholinesterase, Molecular Docking, Ramachandran plot, APOE, APP, PSEN1, PSEN2, BLAST, Z-Score.
Field	Biology > Genetics / Molecular
Published In	Volume 5, Issue 3, May-June 2023
Published On	2023-06-10
Cite This	Docking of Alkaloid as a Source of Potential Anticholinesterase Inhibitors for the Treatment of Alzheimer’s Disease - Sonali Priyadarsini, Debasmita Roy, Priyanka Prusty, Kajal Kiran Sahoo, Dharitri Priyadarsini, Rajat Kumar Nayak - IJFMR Volume 5, Issue 3, May-June 2023. DOI 10.36948/ijfmr.2023.v05i03.3676
DOI	https://doi.org/10.36948/ijfmr.2023.v05i03.3676
Short DOI	https://doi.org/gscdpn

View / Download PDF File

E-ISSN 2582-2160

doi

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads

Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 6 Isu 4 Cover Page Vol 6 Isu 3 Cover Page Vol 6 Isu 2

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA

About IJFMR Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us		+91-9898-5948-55	editor@ijfmr.com

International Journal For Multidisciplinary Research

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Docking of Alkaloid as a Source of Potential Anticholinesterase Inhibitors for the Treatment of Alzheimer’s Disease

Share this