International Journal For Multidisciplinary Research

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A Systematic Review on the Effectiveness of Cognitive Behavioral Therapy (CBT) Compared to Antidepressant Medications (ADM) on Adults with Depressive Disorder

Author(s) Clyde Cyril Lubaton Baculio, Kristle Chiara M. De Los Santos, Lydy Grace L. Segurola
Country Philippines
Abstract The increasing prevalence of depression necessitates effective treatment strategies, particularly in understanding the relative efficacy of Cognitive Behavioral Therapy (CBT) and Antidepressant Medications (ADM). This study systematically reviews the literature to compare the effectiveness of Cognitive Behavioral Therapy (CBT) as a monotherapy versus its use as a supplementary therapy alongside Antidepressant Medications (ADM) in managing depressive symptoms among adults. A comprehensive search was conducted across PubMed, Cochrane Library, and EBSCOhost, identifying primary Randomized Controlled Trials (RCTs) published between January 1, 2014, and August 1, 2024. The search yielded 565 studies, which were narrowed down to five Randomized Controlled Trials (RCTs) after rigorous screening against predefined inclusion and exclusion criteria. The selected studies provide compelling evidence that Cognitive Behavioral Therapy (CBT) significantly reduces depressive symptoms and improves remission rates across various patient populations. Key findings include Nakagawa et al. (2017), which demonstrated that patients receiving Cognitive Behavioral Therapy (CBT) plus Treatment as Usual (TAU) experienced a greater reduction in depressive symptoms compared to those receiving Treatment as Usual (TAU) alone, with sustained effects over 12 months. Fredlan and colleagues (2015) reported significant reductions in Beck Depression Inventory-II scores among heart failure patients receiving Cognitive Behavioral Therapy (CBT), highlighting its effectiveness in diverse settings. Additionally, Petrak et al. (2015) found that while both Cognitive Behavioral Therapy (CBT) and sertraline were effective, sertraline showed a slight advantage in remission rates for patients with poorly controlled diabetes. Button et al. (2015) and Wiles et al. (2014) further supported the efficacy of combining Cognitive Behavioral Therapy (CBT) with usual care or pharmacotherapy. The results underscore the potential for a holistic approach that integrates Cognitive Behavioral Therapy (CBT) with Antidepressant Medications (ADM) to address both cognitive and biochemical aspects of depression, leading to enhanced long-term outcomes. This study provides valuable insights that can inform clinical decision-making and improve patient care trajectories in managing depressive disorders.
Keywords Cognitive Behavioral Therapy, Antidepressant Medications, Depressive Disorder, Adults with Depressive Disorder, Randomized Controlled Trial, Systematic Review
Field Medical / Pharmacy
Published In Volume 7, Issue 1, January-February 2025
Published On 2025-02-13
Cite This A Systematic Review on the Effectiveness of Cognitive Behavioral Therapy (CBT) Compared to Antidepressant Medications (ADM) on Adults with Depressive Disorder - Clyde Cyril Lubaton Baculio, Kristle Chiara M. De Los Santos, Lydy Grace L. Segurola - IJFMR Volume 7, Issue 1, January-February 2025. DOI 10.36948/ijfmr.2025.v07i01.37000
DOI https://doi.org/10.36948/ijfmr.2025.v07i01.37000
Short DOI https://doi.org/g84xgr
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