International Journal For Multidisciplinary Research

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Pharmacist’s Role In Pharmacogenomics And Pain Management

Author(s) Dr. Nirlepkumar Patel
Country United States
Abstract Medication for pain relief is an essential aspect of treatment. However, this area often becomes challenging when treating patients due to the heterogeneous reaction to the analgesic medication for each patient. The reliability of the medicine has improved with the increasing availability of information regarding pharmacogenomics, which is known to improve medicine by enabling it to be tailored to a person's unique genetic makeup. This review examines the polymorphisms in cytochrome P450 enzymes (for example, CYP2D6, CYP2C9) and other markers in OPRM1, COMT, and ABCB1 that have been shown to modify the efficacy and safety of pain medications. It also recommends how therapy can be optimized; for example, it suggests using opioids and NSAIDs based on the pharmacogenomic profile of the patient. The work of pharmacists in a multidisciplinary team in the interpretation of pharmacogenomic tests, modification of the treatment regimen, and communication with the patient regarding genetic testing is discussed, as well as their involvement in multidisciplinary teams. There are also positive developments in the reform of pharmacogenomic research and educational and legislative policy that mitigate barriers associated with the cost, availability, and inclusivity of participants. Pharmacogenomics can change the pain management practice by enhancing pharmacotherapy, managing side effects, and accelerating patient-centered care. Further, this article calls for more resources in the form of practical tools and training to help expand the use of pharmacogenomics and its applications more readily in direct patient care.
Keywords CYP2D6 Metabolism, Opioid Pharmacogenomics, NSAID Safety, Pharmacogenomic Markers, OPRM1 Gene, COMT (catechol-O-methyltransferase) Variants, P-Glycoprotein (ABCB1)
Published In Volume 1, Issue 1, July-August 2019
Published On 2019-07-03
DOI https://doi.org/10.36948/ijfmr.2019.v01i01.37525
Short DOI https://doi.org/g85smf
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