International Journal For Multidisciplinary Research

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Assessment of in Vitro Immunomodulatory Activity of Ethanolic Extract of Crataeva Nurvula Buch. Ham. Bark

Author(s) Aparna Lakshmi I, Prakashitha Goud, CH Sudha Bhargavi
Country India
Abstract The current study was carried out to assess the immunomodulatory activity of Ethanolic extract Crataeva nurvula bark (EECNB) using in vitro methods.
In vitro immune modulatory activity was investigated by cellular lysosomal enzyme assay and phagocytosis evaluation.
The release of cellular lysosomal enzyme was found to be significant (p<0.05) at 200 μg/ml (Stimulation Index = 1.982) and 100 μg/ml (S.I= 1.564) of EECN with respect to control PHA (Stimulation Index =1.00) maximum phagocytic activity of EECNB was evident at 500g/ml and With gradual increase in the dilutions of the plant extract there was a corresponding decrease in phagocytic activity.
The present has demonstrated the immunomodulatory potential of EECNB (as it has good stimulation index and maximum phagocytic activity) based on the results of lysosomal and phagocytosis assay. Further studies are needed to support its immonumodulatory activity.
Keywords Immunomodulatory, Crataeva nurvula, phagocytosis, lysosomal enzyme
Field Chemistry > Pharmacy
Published In Volume 5, Issue 3, May-June 2023
Published On 2023-06-19
Cite This Assessment of in Vitro Immunomodulatory Activity of Ethanolic Extract of Crataeva Nurvula Buch. Ham. Bark - Aparna Lakshmi I, Prakashitha Goud, CH Sudha Bhargavi - IJFMR Volume 5, Issue 3, May-June 2023. DOI 10.36948/ijfmr.2023.v05i03.3824
DOI https://doi.org/10.36948/ijfmr.2023.v05i03.3824
Short DOI https://doi.org/gsct3w
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