International Journal For Multidisciplinary Research

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Biological Evaluation and Pharmacological Potential of Heterocyclic N-bridged S-triazole Scaffolds: a Comprehensive Review

Author(s) Prof. Dr. Channamma G Majage, Priyanka Shetty Shetty, Kishore Singh C Singh, Ashok Kumar M Malpani, Md. Naveed Ahmed Ahmed
Country India
Abstract 1,2,4-Triazole and its derivatives have emerged as crucial scaffolds in medicinal chemistry due to their diverse biological activities. This review comprehensively explores recent advancements in the synthesis and evaluation of 1,2,4-triazole derivatives for their antimicrobial, antifungal, antiproliferative, anticancer, anti-inflammatory, and insecticidal properties. Several studies have highlighted the potential of these compounds in treating tuberculosis, fungal infections, and various cancers, demonstrating their significance in drug discovery.
For instance, certain 1,2,4-triazole derivatives exhibit remarkable antimycobacterial activity by inhibiting the KatG enzyme, leading to oxidative damage in Mycobacterium tuberculosis. Other derivatives have demonstrated potent antifungal effects against Rhizoctonia solani by disrupting mycelial cell membranes. Additionally, specific compounds have shown promising cytotoxicity against cancer cell lines such as MCF-7, HeLa, and A549, with some derivatives outperforming standard chemotherapeutic agents. The structural modifications in triazole rings, including substitutions at different positions, have significantly influenced their biological activities, as evidenced by molecular docking and structure-activity relationship (SAR) studies.
Furthermore, triazole-based compounds have been investigated for their anti-inflammatory and insecticidal activities, revealing potential applications beyond traditional antimicrobial and anticancer therapies. The findings from various research articles emphasize the importance of continued exploration of 1,2,4-triazole derivatives to develop novel therapeutic agents with improved efficacy and selectivity. This review provides insights into the latest developments in triazole-based drug discovery, paving the way for future advancements in pharmaceutical research.
Keywords 1,2,4-Triazole, N-Bridged, Biological, Heterocyclic.
Field Chemistry
Published In Volume 7, Issue 2, March-April 2025
Published On 2025-03-26
DOI https://doi.org/10.36948/ijfmr.2025.v07i02.39908
Short DOI https://doi.org/g892pc
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