Sickle Cell Disease

D.RAMA BRHMA REDDY; K.MALLESWARI; A.SATISH; A.KARTHIKEYA SHARMA; B.AVINASH

doi:10.36948/ijfmr.2023.v05i04.5450

Sickle Cell Disease

Author(s)	D.RAMA BRHMA REDDY, K.MALLESWARI, A.SATISH, A.KARTHIKEYA SHARMA, B.AVINASH
Country	India
Abstract	Sickle cell disease and its variants constitute the most common inherited blood disorders affecting millions of individuals worldwide. Significant information regarding the nature of the genetic mutations and modifier genes that result in increased or decreased severity of the disease are available. In recent years, detailed data regarding molecular genetics, pathophysiology, mechanisms for the development of symptoms and side effects of sickle cell disease have been published. The relationship of physiological changes, cellular interactions, coexisting coagulation disorders, effects of association with other genetic disorders and a number of intervening factors have been explored. New techniques for pre-conception, prenatal, in utero, and neonatal screening are available. Means for prediction of the severity of the disease, clinical course of the disorder, and prevention of some of its major complications have been developed. The effects of psychosocial and environmental factors have been explored. Various therapeutic strategies including bone marrow and stem cell transplantation are currently employed in the treatment of patients with sickle cell disease. Recent progress in understanding the molecular pathways controlling mammalian erythropoiesis and globin switching, as well as advances in genome engineering, particularly the gene-editing techniques, have opened a venue for genetic-based treatment of the disease. Currently, sickle cell disease is often associated with a high rate of complications and mortality. The development of new pharmacological agents, methods for gene therapy, and alterations and modification of the coexisting genetic factors and modifiers for treatment of the disease are encouraging.
Keywords	sicklecelldisease,genetics,etiology,pathophysiology,symptoms,screening,diagnosis,complications,treatment,coagulation,inflammatory factors, modifiers,genetherapy, transplantation.
Field	Chemistry > Pharmacy
Published In	Volume 5, Issue 4, July-August 2023
Published On	2023-08-22
Cite This	Sickle Cell Disease - D.RAMA BRHMA REDDY, K.MALLESWARI, A.SATISH, A.KARTHIKEYA SHARMA, B.AVINASH - IJFMR Volume 5, Issue 4, July-August 2023. DOI 10.36948/ijfmr.2023.v05i04.5450
DOI	https://doi.org/10.36948/ijfmr.2023.v05i04.5450
Short DOI	https://doi.org/gsm4zg

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International Journal For Multidisciplinary Research

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Sickle Cell Disease

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