International Journal For Multidisciplinary Research

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Case Series Of Various Mixed Connective Tissue Disorder Cases That Presented To Sapthagiri Hospital Over The Past 2 Years

Author(s) Pandhare Rushikesh Hemant, Madhusudhan C, Teena chandran
Country India
Abstract Background: Mixed connective tissue disease (MCTD) is a rare autoimmune disease, characterized by the production of specific autoantibody anti-RNP, which presents with varied overlapping symptoms of different connective tissue disorders. The aim of this study is to identify the frequency and patterns of MCTD.

Objective :To demonstrate the clinical profile,immunological profile of MCTD patients and adverse events developed during the duration of treatment

Design :Prospective observational study

Setting : A large, academic, tertiary medical center

Methodology:All MCTD cases admitted in Sapthagiri Institute of Medical Sciences and Research Centre was included.Data was collected through a prepared performa.Patients were followed up till death or discharge.

Results:All 10 cases of MCTD, U1RNP is positive.
8 of the 10 cases were treated aggressively with immunosuppressants.
Most common secondary infection was Pneumonia.
One patient developed Abdominal TB
One patient developed avascular necrosis of femur secondary to high dose steroids.


Interpretation and conclusion:It can be noted that even though the relapse rate was lower among patient treated aggressively the chance of developing secondary infection was very high
Hence it is important to monitor the cases which are treated with immunosuppressants, for early diagnosis and treatment of any adverse events.
Keywords MCTD,Pneumonia,avascular necrosis
Field Medical / Pharmacy
Published In Volume 5, Issue 5, September-October 2023
Published On 2023-09-22
Cite This Case Series Of Various Mixed Connective Tissue Disorder Cases That Presented To Sapthagiri Hospital Over The Past 2 Years - Pandhare Rushikesh Hemant, Madhusudhan C, Teena chandran - IJFMR Volume 5, Issue 5, September-October 2023. DOI 10.36948/ijfmr.2023.v05i05.6764
DOI https://doi.org/10.36948/ijfmr.2023.v05i05.6764
Short DOI https://doi.org/gssfkk
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