International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Drug Solubility: Importance and Enhancement Techniques

Author(s) Sanika Chandrakant Deokate, Aditya Abaso deokate, Saurabh Bapu Sangale, Tejrag Popat Gawade
Country India
Abstract One of the key factors in achieving the optimum drug concentration in the systemic circulation for the desired (expected) pharmacological response is solubility, the phenomenon of solute dissolving in solvent to produce a homogeneous system. The main issue in developing formulations for new chemical entities as well as for generic development is low water solubility. Over 40% of NCES (new chemical entities) created in the pharmaceutical business are essentially water Insoluble. A significant difficulty for formulation scientists is solubility. Any medicine that is to be absorbed must be present in solution at the absorption site. Poorly soluble medications can be made more soluble using a variety of strategies, including physical and chemical drug changes and other approaches like Changed Words – Structural Changes Longest Unchanged Words particle reduction, crystal engineering, salt creation, solid dispersion, surfactant use, complexation, and other processes. The choice of a solubility-improving technique depends on the drug’s properties, the site of absorption, and the requirements for the dosage form.
Keywords solubility, homogeneous, particle size, chemical modification ,salt formulation.
Field Medical / Pharmacy
Published In Volume 5, Issue 5, September-October 2023
Published On 2023-10-07
DOI https://doi.org/10.36948/ijfmr.2023.v05i05.7146
Short DOI https://doi.org/gst3tq
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E-ISSN 2582-2160
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