Volumetric MRI Evaluation of Pituitary Gland in North Indian Subjects with Non-diseased Pituitary: Setting the Standards for Normative Data

Dr. Suheel Ur Rahman; Dr. Sheikh Musadiq Adil; Dr. Rassieq Aslam; Dr. Majid Jahengir

doi:10.36948/ijfmr.2022.v04i05.021

Volumetric MRI Evaluation of Pituitary Gland in North Indian Subjects with Non-diseased Pituitary: Setting the Standards for Normative Data

Author(s)	Dr. Suheel Ur Rahman, Dr. Sheikh Musadiq Adil, Dr. Rassieq Aslam, Dr. Majid Jahengir
Country	India
Abstract	Introduction The pituitary gland, also called the master gland, was first described by a Belgian scientist Andreas Vesalius in 1543. Pituitary gland is the engine of normal human physiology and its size and volume changes normally during various physiological stages as well as in various pathological processes, so it becomes imperative to have a normal reference value for a particular population to differentiate the normal and pathological pituitary gland. It is a tiny endocrine gland and is found in sella turcica (meaning Turkish Saddle) of sphenoid. Our study was designed to obtain standardized reference values for the volumes of pituitary gland among North Indian population to analyze the potential diagnostic values of pituitary gland volumetric variation with respect to age and gender. The volume of the pituitary gland was measured using a thin‑section three‑dimensional (3D) magnetic resonance imaging (MRI) with a section thickness of 1 mm. Methods The study was conducted between 2018-21 on patients with non-diseased pituitary by performing T1-multiplanar sequence and calculating pituitary volume by using Di chiro & Nelson formula. MRI was performed on a Siemens 3 Tesla MRI scanner unit. High resolution Multiplanar-T1 Weighted images were obtained with following parameters: Slice thickness: 1 mm, Acquisition plane: Sagittal & Coronal TR 1180 MS, TE 4.4 MS, Flip angle: 15 degrees, Matrix size: 256 × 256, FOV: 24 × 24 cm. Volume = 0.52 × Depth in Sagittal Plane × Height in Sagittal Plane × Width in Coronal Plane Results There were 152 patients included in the study. The mean age of participants was 43.50 years. Age group of 20-30 years comprised the maximum number of patient’s .The overall mean pituitary volume was 277.96 mm3 and in males the mean pituitary was 267.74 mm3 while in females the mean volume was 288.74 mm3. The largest pituitary gland volumes were 401.94 mm3 and 369.86 mm3 in females and males respectively in 10–20-year group while 319.18 mm3 and 360.49 mm3 in females and males respectively in 20-30 years age group. Beyond 70 years and children age group less than 10 years showed the smallest pituitary. Mean pituitary depth was 9.40 mm. Mean pituitary width was 8.81 mm.
Keywords	Pituitary Volume, Magnetic Resonance Imaging, Growth Hormone Deficiency, Idiopathic Short Stature
Field	Medical / Pharmacy
Published In	Volume 4, Issue 5, September-October 2022
Published On	2022-09-09
Cite This	Volumetric MRI Evaluation of Pituitary Gland in North Indian Subjects with Non-diseased Pituitary: Setting the Standards for Normative Data - Dr. Suheel Ur Rahman, Dr. Sheikh Musadiq Adil, Dr. Rassieq Aslam, Dr. Majid Jahengir - IJFMR Volume 4, Issue 5, September-October 2022. DOI 10.36948/ijfmr.2022.v04i05.021
DOI	https://doi.org/10.36948/ijfmr.2022.v04i05.021
Short DOI	https://doi.org/10/gqvmx5

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Volumetric MRI Evaluation of Pituitary Gland in North Indian Subjects with Non-diseased Pituitary: Setting the Standards for Normative Data

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