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International Journal For Multidisciplinary Research
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Novel Synthesis and Characterization of Some Chlorosubstituted Aryl Substituted 1,3-thiazole as Antibacterial Agents
Author(s) | C.D.BADNAKHE |
---|---|
Country | India |
Abstract | The synthesis, spectral analysis and biological activities of 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one- 2-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (8d2) (J”) have been carried out. In this case 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(heptan-1-one)-2- amino-1,3-thiazole (8d) (J), 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one-2-[(2-hydroxy-3,5-dichlorophenyl) ethanonylamino]-1,3-thiazole (8d1) (J’) & 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one- 2-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (8d2) (J”) have been screened. The compound (J) was synthesized from 1-(2’-Hydroxy-3’,5’-dichlorophenyl)-2-bromo-1,3-nonanedione (a4) by the action of thiourea, while (J”) was synthesized from (J) by reaction with α-bromo, 2-hydroxy-3,5 dichloroacetophenone to get 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one-2-[(2-hydroxy-3,5-dichlorophenyl)ethanonylamino]-1,3-thiazole (8d1) (J’). Further (J’) on treatment with KSCN was dissolved in acetic acid gave (J’’). The nanoparticles of the compounds J, J’and J’’ have been prepared by using ultrasonic technique. The newly synthesized titled compound and it’s nanoparticles were screened for their antibacterial activity against some pathogens ; Gram+ve bacteria viz. Staphylococcus pneumoniae, Staphylococcus aureus and Gram-ve bacteria viz. Escherichia coli and Pseudomonas fluorescens by using agar disc diffusion method.All the newly synthesized compounds were found to be active against test pathogens. |
Keywords | Chalcone, thiazine, thiourea, α-bromo,2-hydroxy-3,5 dichloroacetophenone, KSCN was dissolved in acetic acid, antibacterial assay. |
Field | Chemistry |
Published In | Volume 5, Issue 5, September-October 2023 |
Published On | 2023-10-27 |
Cite This | Novel Synthesis and Characterization of Some Chlorosubstituted Aryl Substituted 1,3-thiazole as Antibacterial Agents - C.D.BADNAKHE - IJFMR Volume 5, Issue 5, September-October 2023. DOI 10.36948/ijfmr.2023.v05i05.7937 |
DOI | https://doi.org/10.36948/ijfmr.2023.v05i05.7937 |
Short DOI | https://doi.org/gszvh7 |
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