Novel Synthesis and Characterization of Some Chlorosubstituted Aryl Substituted 1,3-thiazole as Antibacterial Agents

C.D.BADNAKHE

doi:10.36948/ijfmr.2023.v05i05.7937

Novel Synthesis and Characterization of Some Chlorosubstituted Aryl Substituted 1,3-thiazole as Antibacterial Agents

Author(s)	C.D.BADNAKHE
Country	India
Abstract	The synthesis, spectral analysis and biological activities of 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one- 2-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (8d2) (J”) have been carried out. In this case 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-(heptan-1-one)-2- amino-1,3-thiazole (8d) (J), 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one-2-[(2-hydroxy-3,5-dichlorophenyl) ethanonylamino]-1,3-thiazole (8d1) (J’) & 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one- 2-[4-(2-hydroxy-3,5-dichlorophenyl)-2-mercapto-imidazolo]-1,3-thiazole (8d2) (J”) have been screened. The compound (J) was synthesized from 1-(2’-Hydroxy-3’,5’-dichlorophenyl)-2-bromo-1,3-nonanedione (a4) by the action of thiourea, while (J”) was synthesized from (J) by reaction with α-bromo, 2-hydroxy-3,5 dichloroacetophenone to get 5-(2’-hydroxy-3’,5’-dichlorophenyl)-4-heptan-1-one-2-[(2-hydroxy-3,5-dichlorophenyl)ethanonylamino]-1,3-thiazole (8d1) (J’). Further (J’) on treatment with KSCN was dissolved in acetic acid gave (J’’). The nanoparticles of the compounds J, J’and J’’ have been prepared by using ultrasonic technique. The newly synthesized titled compound and it’s nanoparticles were screened for their antibacterial activity against some pathogens ; Gram+ve bacteria viz. Staphylococcus pneumoniae, Staphylococcus aureus and Gram-ve bacteria viz. Escherichia coli and Pseudomonas fluorescens by using agar disc diffusion method.All the newly synthesized compounds were found to be active against test pathogens.
Keywords	Chalcone, thiazine, thiourea, α-bromo,2-hydroxy-3,5 dichloroacetophenone, KSCN was dissolved in acetic acid, antibacterial assay.
Field	Chemistry
Published In	Volume 5, Issue 5, September-October 2023
Published On	2023-10-27
Cite This	Novel Synthesis and Characterization of Some Chlorosubstituted Aryl Substituted 1,3-thiazole as Antibacterial Agents - C.D.BADNAKHE - IJFMR Volume 5, Issue 5, September-October 2023. DOI 10.36948/ijfmr.2023.v05i05.7937
DOI	https://doi.org/10.36948/ijfmr.2023.v05i05.7937
Short DOI	https://doi.org/gszvh7

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Novel Synthesis and Characterization of Some Chlorosubstituted Aryl Substituted 1,3-thiazole as Antibacterial Agents

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