International Journal For Multidisciplinary Research

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To Evaluate the Absorption, Elimination Pattern of Ricinus Communis, using Rabbit as a Tool

Author(s) Manjusha V Nikale
Country India
Abstract Pharmacokinetics is a study of movement of a drug in our body. Usually a modern drug will consists of the ingredient and excipients. It is relatively easy to trace the pharmacokinetics of the modern drug. In case of herbal medicines, usually most of the over the counter products are polyherbal. There is no component clearly said to be the active principle responsible for the dedicated medicinal effect. Hence one needs to establish some phytochemical markers for the identification of the herb(s) in the blood, which can be used to trace the fate of the drug in the living system. This will help us to establish the absorption elimination process of the herb. The markers thus obtained need not be the active principle or constituent of the drug. This will help to decide the dosage regime and the therapeutic window of the drug. The present work was undertaken with an objective to establish a phytochemical marker for the detection of Ricinus communis in the blood of rabbits and to establish the pharmacokinetics of the herb. One component was identified from Ricinus communis in the plasma of the rabbits fed with the leaf powder of Ricinus comunis as a dose. The phytochemical could be detected using HPLC at Rt 5.707 minutes for Ricinus communis. This phytochemical was used to establish the pharmacokinetics of leaf powder of Ricinus communis.
Keywords Key words: - Markers, Ricinus communis, RP-HPLC, Pharmacokinetics.
Field Biology > Agriculture / Botany
Published In Volume 5, Issue 6, November-December 2023
Published On 2023-11-12
Cite This To Evaluate the Absorption, Elimination Pattern of Ricinus Communis, using Rabbit as a Tool - Manjusha V Nikale - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.8648
DOI https://doi.org/10.36948/ijfmr.2023.v05i06.8648
Short DOI https://doi.org/gs4xsv
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