The Future of Painless Injection: Exploring the Materials Used, Manufacturing Materials and It’s Applications in Transdermal Drug Delivery System

Rakshith; Naidu Hemant Vijay; Aravind

doi:10.36948/ijfmr.2023.v05i06.9153

The Future of Painless Injection: Exploring the Materials Used, Manufacturing Materials and It’s Applications in Transdermal Drug Delivery System

Author(s)	Rakshith, Naidu Hemant Vijay, Aravind
Country	India
Abstract	This article review’s about the high barrier qualities of biological membranes, such as the stratum corneum (SC) of the skin or the sclera/cornea of the eye, among others, many therapeutic medicines that have the potential to be very effective are constrained by their inability to reach the systemic circulation. The SC, the skin's outermost layer, serves as the main deterrent to drugs given topically. Thus, the intact SC acts as the body's primary defense against foreign chemicals, such as pharmaceuticals. The only medications that can be successfully supplied transdermally are those with very particular physicochemical characteristics (molecular weight 500 Da, sufficient lipophilicity, and low melting point). It is difficult to administer hydrophilic medications and macromolecular targets including peptides, DNA, and small interfering RNA transdermally. Therefore, bypass or reversible disruption may be used to facilitate medication penetration through the SC. When used to penetrate skin, microneedles (MNs) will bypass the SC, form temporary micron-sized aqueous transport channels, and increase transdermal permeability. Since these micro pores are several orders of magnitude larger than molecular dimensions, hydrophilic macromolecules should easily be able to go through them. Many research teams and pharmaceutical businesses around the world have used different methods to create MNs. This review describes different MN types and fabrication processes.
Keywords	TRANSDERMAL DRUG DELIVERY SYSTEM (TDDS), MATERIALS, MICRONEEDLES, TYPES , APPLICATIONS, DEVICES USED AS MICRONEEDLES.
Field	Medical / Pharmacy
Published In	Volume 5, Issue 6, November-December 2023
Published On	2023-11-18
Cite This	The Future of Painless Injection: Exploring the Materials Used, Manufacturing Materials and It’s Applications in Transdermal Drug Delivery System - Rakshith, Naidu Hemant Vijay, Aravind - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.9153
DOI	https://doi.org/10.36948/ijfmr.2023.v05i06.9153
Short DOI	https://doi.org/gs5mft

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The Future of Painless Injection: Exploring the Materials Used, Manufacturing Materials and It’s Applications in Transdermal Drug Delivery System

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