International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 6 Issue 6 November-December 2024 Submit your research before last 3 days of December to publish your research paper in the issue of November-December.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 6 Issue 6
November-December 2024

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Unmodified Polystyrene Nanoparticles Induce Inflammatory and Oxidative Stress Responses in Human Lung Epithelial Cells

Author(s) Dr. Sharmuy Saimon Mano
Country India
Abstract Polystyrene (PS) is one of the commercially used polymers considered as a pollutant in both aquatic and terrestrial environments. Moreover, PS-NPs are used in nanosensors and nanocarrier for the drug. Thus, it is crucial to determine the potential toxicological effect of PS-NPs to cells. Here we used varying concentrations of unmodified PS-NPs of 60±12 nm in size and analyzed their cyto-toxic effect and stress and toxicity gene expressions in NCI-H292 cells. NCI-H292 cells were ex-posed to minimum of 5 µg/mL and maximum of 50 µg/mL of PS-NPs; 50 µg/mL of PS-NPs showed about 50% cell viability. Moreover, unmodified PS-NPs and induce expressions of stress-related genes, such as those encoding interleukin 6 (IL 6), colony-stimulating factor 2 (CSF 2), C-X-C motif chemokine 10 (CXCL 10) responsible for inflammation and heme oxygenase 1 (HMOX 1) responsible for oxidative stress in NCI-H292 cell lines. Our findings suggest that PS-NPs are considered as a potential toxicological compound to the human cell line.
Keywords Nanoparticles, Polystyrene, Nanotoxicology, Lung epithelial cells, gene expression, inflammation
Published In Volume 5, Issue 6, November-December 2023
Published On 2023-11-22
Cite This Unmodified Polystyrene Nanoparticles Induce Inflammatory and Oxidative Stress Responses in Human Lung Epithelial Cells - Dr. Sharmuy Saimon Mano - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.9270
DOI https://doi.org/10.36948/ijfmr.2023.v05i06.9270
Short DOI https://doi.org/gs63xf
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 6 Isu 6Cover Page Vol 6 Isu 5Cover Page Vol 6 Isu 4

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9898-5948-55 editor@ijfmr.com