International Journal For Multidisciplinary Research

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Unmodified Polystyrene Nanoparticles Induce Inflammatory and Oxidative Stress Responses in Human Lung Epithelial Cells

Author(s) Dr. Sharmuy Saimon Mano
Country India
Abstract Polystyrene (PS) is one of the commercially used polymers considered as a pollutant in both aquatic and terrestrial environments. Moreover, PS-NPs are used in nanosensors and nanocarrier for the drug. Thus, it is crucial to determine the potential toxicological effect of PS-NPs to cells. Here we used varying concentrations of unmodified PS-NPs of 60±12 nm in size and analyzed their cyto-toxic effect and stress and toxicity gene expressions in NCI-H292 cells. NCI-H292 cells were ex-posed to minimum of 5 µg/mL and maximum of 50 µg/mL of PS-NPs; 50 µg/mL of PS-NPs showed about 50% cell viability. Moreover, unmodified PS-NPs and induce expressions of stress-related genes, such as those encoding interleukin 6 (IL 6), colony-stimulating factor 2 (CSF 2), C-X-C motif chemokine 10 (CXCL 10) responsible for inflammation and heme oxygenase 1 (HMOX 1) responsible for oxidative stress in NCI-H292 cell lines. Our findings suggest that PS-NPs are considered as a potential toxicological compound to the human cell line.
Keywords Nanoparticles, Polystyrene, Nanotoxicology, Lung epithelial cells, gene expression, inflammation
Published In Volume 5, Issue 6, November-December 2023
Published On 2023-11-22
Cite This Unmodified Polystyrene Nanoparticles Induce Inflammatory and Oxidative Stress Responses in Human Lung Epithelial Cells - Dr. Sharmuy Saimon Mano - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.9270
DOI https://doi.org/10.36948/ijfmr.2023.v05i06.9270
Short DOI https://doi.org/gs63xf
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