International Journal For Multidisciplinary Research

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Comparative Evaluation of Antifungal Action of Tea Tree Oil, Cinnamon Oil and Fluconazole on Heat Polymerized Acrylic Denture Base Resin - an in Vitro Study

Author(s) Poojya Ramdev, Shruthi C S
Country India
Abstract Introduction
Denture stomatitis, also known as chronic atrophic candidiasis or denture sore mouth, is an inflammation of the oral cavity prevalent in 11-67% of geriatric complete denture wearers. Candida albicans is a commensal of the oral cavity, but it becomes pathogenic due to local or systemic predisposition, caused by chronic irritation or immune deficiency. Several investigators have demonstrated that Candida albicans colonies are more frequently isolated from the tissue-fitting surfaces of acrylic resin dentures than from the corresponding mucosa. While fluconazole is an established antifungal medication, exploring natural alternatives, like tea tree oil and cinnamon oil holds significant value. These essential oils possess potential antifungal properties and might offer advantages like reduced side effects or easier application.
Materials and methodology
Sixty heat cure acrylic resin specimens of 20 mm length, 8 mm width, and 1.5 mm thickness (20 x 8 x 1.5mm) were prepared using specimen wax patterns, cut from base plate wax. The 60 wax patterns were then invested in a denture flask using compression mould technique. Pure cultures of Candida albicans were grown on Sabouraud agar plates containing 500mmol /L of sucrose at 25°C. After 24 hours, the colonies were suspended in tubes containing 5 ml of BHI broth. To facilitate the initial colonization of the acrylic resin surfaces, the specimens were then placed in tubes containing BHI broth plus inoculum and allowed to stand for 11 hours at 37°C. The 60 specimens were distributed into three test groups and one control group. This in vitro study investigated the antifungal efficacy of various agents against Candida albicans, a fungus associated with denture stomatitis. We compared the effectiveness of tea tree oil, fluconazole- a common antifungal medication, cinnamon oil, and saline (control) over a 14-day period. Fungal growth was monitored by measuring optical density (OD).
Results
The finding suggests that tea tree oil effectively inhibits the growth of Candida albicans. Fluconazole also exhibited some antifungal activity, with a mean OD value of 0.2311 ± 0.1533. While this suggests a degree of effectiveness, it appears less pronounced compared to tea tree oil. Cinnamon oil exhibited some antifungal activity as well, with a mean OD value of 0.4263 ± 0.1037. This was lower than the control group (saline) with a mean OD value of 1.6201 ± 0.5429.
Conclusion
Among the tested agents, tea tree oil displayed the most potent antifungal activity against Candida albicans throughout the experiment. This is evidenced by the significantly lower mean OD value (0.1530 ± 0.0351; p < 0.001) compared to all other groups.
Keywords denture stomatitis, heat polymerized acrylic resin, antifungal agents
Field Medical / Pharmacy
Published In Volume 6, Issue 3, May-June 2024
Published On 2024-06-01
Cite This Comparative Evaluation of Antifungal Action of Tea Tree Oil, Cinnamon Oil and Fluconazole on Heat Polymerized Acrylic Denture Base Resin - an in Vitro Study - Poojya Ramdev, Shruthi C S - IJFMR Volume 6, Issue 3, May-June 2024. DOI 10.36948/ijfmr.2024.v06i03.21349
DOI https://doi.org/10.36948/ijfmr.2024.v06i03.21349
Short DOI https://doi.org/gtw6sf
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