Unveiling an Antibiofilm Marvel to Combat Antibiotics Resistance

Sushil Kumar Mali; Sumit Kumar Gupta; Ram Prakash Yadav; Shivani Sharma; Rajat

doi:10.36948/ijfmr.2023.v05i06.8821

Unveiling an Antibiofilm Marvel to Combat Antibiotics Resistance

Author(s)	Sushil Kumar Mali, Sumit Kumar Gupta, Ram Prakash Yadav, Shivani Sharma, Rajat
Country	INDIA
Abstract	Creative approaches are essential to fight against bacterial infections while the worldwide issue of antibiotic resistance keeps growing. To combat the persistent biofilms that bacteria create, which are a major reason for treatment failure, this study presents a novel Antibiofilm Marvel (ABM). We provide an in-depth analysis of the makeup and mode of action of ABM, demonstrating its capacity to rupture and destroy biofilms, increasing the sensitivity of bacteria to traditional antibiotics. Furthermore, the work demonstrates the synergistic impact of ABM when used with currently available antibiotics, leading to a significant recovery in antibacterial efficacy. The present work highlights the need to prioritize biofilm-targeted strategy in the battle against antibiotic resistance and provides a possible path forward for the development of next-generation antibacterial medicines. An important turning point was the introduction of ABM. This review article is focusing on the various antibiofilm agent (synthetic, chelating agents, and antibiotics) along with their mechanisms of inhibition (AHL-mediated quorum sensing inhibition, Extracellular Polysaccharide Substance of Biofilm Dispersion by Enzymes, Inhibition of biofilm by polysaccharides, Inhibition of cell division and survival, Cleavage of peptidoglycan, Inhibition of c-di-GMP signaling system, Neutralization or disassembly of lipopolysaccharides) This article updates the recent findings on the other active antibiofilm agents.
Keywords	Biofilms, Anti-biofilm agent, Biofilm models, Acyl Homo-serine Lactone, Lipopolysaccharides (LPS), Quorum sensing.
Field	Medical / Pharmacy
Published In	Volume 5, Issue 6, November-December 2023
Published On	2023-11-13
Cite This	Unveiling an Antibiofilm Marvel to Combat Antibiotics Resistance - Sushil Kumar Mali, Sumit Kumar Gupta, Ram Prakash Yadav, Shivani Sharma, Rajat - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.8821
DOI	https://doi.org/10.36948/ijfmr.2023.v05i06.8821
Short DOI	https://doi.org/gs4xpv

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Unveiling an Antibiofilm Marvel to Combat Antibiotics Resistance

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